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Transforming growth factor alpha (TGF-α) is a member of the epidermal growth factor (EGF) family. TGF-α can be produced in macrophages, brain cells, and keratinocytes. TGF-α has also been observed to be highly expressed in the suprachiasmatic nucleus (SCN) (5). This finding suggests a role for EGFR signaling in the regulation of CLOCK and circadian rhythms within the SCN. Additional studies have shown that when injected into the third ventricle TGF-α can suppress circadian locomotor behavior along with drinking or eating activities.
Alternate Names - TGFA, TFGA, transforming growth factor alpha, Transforming growth factor - α
Homology Across Species
Acinonyx jubatus (cheetah) TGF-α – 100%
Ailuropoda melanoleuca (giant panda) TGF-α – 100%
Callorhinus ursinus (northern fur seal) TGF-α – 100%
Camelus bactrianus (Bactrian camel) TGF-α – 100%
Camelus dromedarius (Arabian camel) TGF-α – 100%
Canis lupus dingo (dingo) TGF-α – 100%
Canis lupus familiaris (dog) TGF-α – 100%
Ceratotherium simum simum (southern white rhinoceros) TGF-α – 100%
Equus asinus (ass) TGF-α – 100%
Equus caballus (horse) TGF-α – 100%
Equus przewalskii (Przewalski's horse) TGF-α – 100%
Eumetopias jubatus (Steller sea lion) TGF-α – 100%
Felis catus (domestic cat) TGF-α – 100%
Leptonychotes weddellii (Weddell seal) TGF-α – 100%
Loxodonta africana (African savanna elephant) TGF-α – 100%
Lynx pardinus (Spanish lynx) TGF-α – 100%
Mustela putorius furo (domestic ferret) TGF-α – 100%
Neomonachus schauinslandi (Hawaiian monk seal) TGF-α – 100%
Odobenus rosmarus divergens (Pacific walrus) TGF-α – 100%
Panthera pardus (leopard) TGF-α – 100%
Panthera tigris altaica (Amur tiger) TGF-α – 100%
Sus scrofa (pig) TGF-α – 100%
Trichechus manatus latirostris (Florida manatee) TGF-α – 100%
Ursus arctos horribilis (grizzly bear) TGF-α – 100%
Vicugna pacos (alpaca) TGF-α – 100%
Zalophus californianus (California sea lion) TGF-α – 100%
More… https://blast.ncbi.nlm.nih.gov
VVSHFNDCPD SHSQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA (50)
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